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2016 ; 3
(ä): 35
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Coagulation complications following trauma
#MMPMID27895932
Martini WZ
Mil Med Res
2016[]; 3
(ä): 35
PMID27895932
show ga
Traumatic injury is one of the leading causes of death, with uncontrolled
hemorrhage from coagulation dysfunction as one of the main potentially
preventable causes of the mortality. Hypothermia, acidosis, and resuscitative
hemodilution have been considered as the significant contributors to coagulation
manifestations following trauma, known as the lethal triad. Over the past decade,
clinical observations showed that coagulopathy may be present as early as
hospital admission in some severely injured trauma patients. The hemostatic
dysfunction is associated with higher blood transfusion requirements, longer
hospital stay, and higher mortality. The recognition of this early coagulopathy
has initiated tremendous interest and effort in the trauma community to expand
our understanding of the underlying pathophysiology and improve clinical
treatments. This review discusses the current knowledge of coagulation
complications following trauma.
|*Blood Coagulation Disorders
[MESH]
|*Hemorrhage/complications/physiopathology
[MESH]
|*Wounds and Injuries/complications/physiopathology
[MESH]