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2010 ; 30
(1
): 329-42
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Clostridium difficile
#MMPMID20513554
Curry S
Clin Lab Med
2010[Mar]; 30
(1
): 329-42
PMID20513554
show ga
Clostridium difficile has re-emerged as a major hospital-acquired infection since
2001. Despite development of polymerase chain reaction-based testing, no single
clinical diagnostic test has emerged with sufficient sensitivity, specificity,
and turnaround time to be entirely reliable for disease diagnosis. The importance
of C difficile acquired outside the hospital environment remains an unknown
factor and awaits further epidemiologic investigation. This article discusses the
changing epidemiology, clinical presentation, and pathogenesis of C difficile
infection and highlights the ongoing challenges of laboratory diagnosis,
treatment, and disease relapse.