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10.1016/j.semcdb.2016.08.028 http://scihub22266oqcxt.onion/10.1016/j.semcdb.2016.08.028 C5330947!5330947 !27582427     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27582427 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Semin+Cell+Dev+Biol 2017 ; 64 (ä): 79-89 Nephropedia Template TP {{tp|p=27582427 |t=2017. Clonal cooperativity in heterogenous cancers |pdf=|usr=}}{{27582427 }} gab.com Text Clonal cooperativity in heterogenous cancers JO: Semin Cell Dev Biol http://www.kidney.de/pget.php?&tw=1&pmid=27582427 #FOAvip Tumor heterogeneity is a major obstacle to the development of effective therapies and is thus an important focus of cancer research. Genetic and epigenetic alterations, as well as altered tumor microenvironments, result in tumors made up of diverse subclones with different genetic and phenotypic characteristics. Intratumor heterogeneity enables competition, but also supports clonal cooperation via cell-cell contact or secretion of factors, resulting in enhanced tumor progression. Here, we summarize recent findings related to interclonal interactions within a tumor and the therapeutic implications of such interactions, with an emphasis on how different subclones collaborate with each other to promote proliferation, metastasis and therapy-resistance. Furthermore, we propose that disruption of clonal cooperation by targeting key factors (such as Wnt and Hedgehog, amongst others) can be an alternative approach to improving clinical outcomes. Twit Text FOAVip Clonal cooperativity in heterogenous cancers ????Semin Cell Dev Biol http://www.kidney.de/pget.php?&tw=1&pmid=27582427 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27582427 #FOAvip English Wikipedia <ref>{{Cite pmid|27582427 }}</ref> Clonal cooperativity in heterogenous cancers #MMPMID27582427 Zhou H ; Neelakantan D ; Ford HL Semin Cell Dev Biol 2017[Apr]; 64 (ä): 79-89 PMID27582427 show ga Tumor heterogeneity is a major obstacle to the development of effective therapies and is thus an important focus of cancer research. Genetic and epigenetic alterations, as well as altered tumor microenvironments, result in tumors made up of diverse subclones with different genetic and phenotypic characteristics. Intratumor heterogeneity enables competition, but also supports clonal cooperation via cell-cell contact or secretion of factors, resulting in enhanced tumor progression. Here, we summarize recent findings related to interclonal interactions within a tumor and the therapeutic implications of such interactions, with an emphasis on how different subclones collaborate with each other to promote proliferation, metastasis and therapy-resistance. Furthermore, we propose that disruption of clonal cooperation by targeting key factors (such as Wnt and Hedgehog, amongst others) can be an alternative approach to improving clinical outcomes. |*Genetic Heterogeneity [MESH] |Animals [MESH] |Clone Cells [MESH] |Drug Resistance, Neoplasm [MESH] |Humans [MESH] |Models, Biological [MESH]Clonal cooperativity in heterogenous cancers (epmc).pdf DeepDyve Pubget Overpricing