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2015 ; 7
(5
): e27281
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Clomiphene Effects on Idiopathic Premature Ejaculation
#MMPMID26543830
Ketabchi AA
Nephrourol Mon
2015[Sep]; 7
(5
): e27281
PMID26543830
show ga
BACKGROUND: Premature ejaculation (PE) is the inability to delay ejaculation,
occurring sooner than they or their partner would like during sexual activities.
PE is a challenging problem that can affect sexual enjoyment and may harm
relationships of couples and affect their quality of life. In idiopathic PE,
several helpful techniques and medicines are recommended, but none of them has
yielded satisfactory results. OBJECTIVES: Our objective in this study was to
evaluate the efficacy and safety of clomiphene as a selective estrogen receptor
modulator on the treatment of idiopathic PE. PATIENTS AND METHODS: In a
randomized clinical trial, 178 married men with idiopathic PE defined according
to the Diagnostic and Statistical Manual of Mental Disorders Third Revised
Version (DSM-III-R) who referred to urology clinics over a 10-month period in
2012 were randomized into two groups, namely the study (clomiphene) and control
(placebo) groups. They completed self-administered questionnaires that included
intravaginal ejaculatory latency time (IELT), erectile dysfunction indexes,
quality of life (QOL), sociodemographic characteristics, lifestyle, and medical
illness. After 6 months of intervention, all data were compared with the baseline
data and between the groups. RESULTS: Within the 10-month study course, 126
patients (70.8%) completed this study. After intervention and comparison of the
results between the two groups, IELT, sexual indexes, and QOL improved in the
study group, but significant differences were observed only in the IELT and QOL
findings. CONCLUSIONS: Clomiphene seems to be useful in the pharmacological
treatment of PE compared to the placebo.