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10.1038/ng.3441 http://scihub22266oqcxt.onion/10.1038/ng.3441 C4783858!4783858 !26551669     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26551669 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Genet 2015 ; 47 (12 ): 1402-7 Nephropedia Template TP {{tp|p=26551669 |t=2015. Clock-like mutational processes in human somatic cells |pdf=|usr=}}{{26551669 }} gab.com Text Clock-like mutational processes in human somatic cells JO: Nat Genet http://www.kidney.de/pget.php?&tw=1&pmid=26551669 #FOAvip During the course of a lifetime, somatic cells acquire mutations. Different mutational processes may contribute to the mutations accumulated in a cell, with each imprinting a mutational signature on the cell's genome. Some processes generate mutations throughout life at a constant rate in all individuals, and the number of mutations in a cell attributable to these processes will be proportional to the chronological age of the person. Using mutations from 10,250 cancer genomes across 36 cancer types, we investigated clock-like mutational processes that have been operating in normal human cells. Two mutational signatures show clock-like properties. Both exhibit different mutation rates in different tissues. However, their mutation rates are not correlated, indicating that the underlying processes are subject to different biological influences. For one signature, the rate of cell division may influence its mutation rate. This study provides the first survey of clock-like mutational processes operating in human somatic cells. Twit Text FOAVip Clock-like mutational processes in human somatic cells ????Nat Genet http://www.kidney.de/pget.php?&tw=1&pmid=26551669 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26551669 #FOAvip English Wikipedia <ref>{{Cite pmid|26551669 }}</ref> Clock-like mutational processes in human somatic cells #MMPMID26551669 Alexandrov LB ; Jones PH ; Wedge DC ; Sale JE ; Campbell PJ ; Nik-Zainal S ; Stratton MR Nat Genet 2015[Dec]; 47 (12 ): 1402-7 PMID26551669 show ga During the course of a lifetime, somatic cells acquire mutations. Different mutational processes may contribute to the mutations accumulated in a cell, with each imprinting a mutational signature on the cell's genome. Some processes generate mutations throughout life at a constant rate in all individuals, and the number of mutations in a cell attributable to these processes will be proportional to the chronological age of the person. Using mutations from 10,250 cancer genomes across 36 cancer types, we investigated clock-like mutational processes that have been operating in normal human cells. Two mutational signatures show clock-like properties. Both exhibit different mutation rates in different tissues. However, their mutation rates are not correlated, indicating that the underlying processes are subject to different biological influences. For one signature, the rate of cell division may influence its mutation rate. This study provides the first survey of clock-like mutational processes operating in human somatic cells. |*Genome, Human [MESH] |Biological Clocks/*genetics [MESH] |Cell Lineage/*genetics [MESH] |Cell Transformation, Neoplastic/*genetics [MESH] |Embryo, Mammalian/*cytology/metabolism [MESH] |Gene Expression Regulation, Neoplastic [MESH] |Humans [MESH] |Mutation Rate [MESH] |Mutation/*genetics [MESH]Clock-like mutational processes in human somatic cells (epmc).pdf DeepDyve Pubget Overpricing