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10.1016/j.molmed.2014.10.007 http://scihub22266oqcxt.onion/10.1016/j.molmed.2014.10.007 C4862830!4862830 !25457619     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25457619 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Trends+Mol+Med 2014 ; 20 (12 ): 685-93 Nephropedia Template TP {{tp|p=25457619 |t=2014. Clock genes, pancreatic function, and diabetes |pdf=|usr=}}{{25457619 }} gab.com Text Clock genes, pancreatic function, and diabetes JO: Trends Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=25457619 #FOAvip Circadian physiology is responsible for the temporal regulation of metabolism to optimize energy homeostasis throughout the day. Disturbances in the light/dark cycle, sleep/wake schedule, or feeding/activity behavior can affect the circadian function of the clocks located in the brain and peripheral tissues. These alterations have been associated with impaired glucose tolerance and type 2 diabetes. Animal models with molecular manipulation of clock genes and genetic studies in humans also support these links. It has been demonstrated that the endocrine pancreas has an intrinsic self-sustained clock, and recent studies have revealed an important role of clock genes in pancreatic ? cells, glucose homeostasis, and diabetes. Twit Text FOAVip Clock genes, pancreatic function, and diabetes ????Trends Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=25457619 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25457619 #FOAvip English Wikipedia <ref>{{Cite pmid|25457619 }}</ref> Clock genes, pancreatic function, and diabetes #MMPMID25457619 Vieira E ; Burris TP ; Quesada I Trends Mol Med 2014[Dec]; 20 (12 ): 685-93 PMID25457619 show ga Circadian physiology is responsible for the temporal regulation of metabolism to optimize energy homeostasis throughout the day. Disturbances in the light/dark cycle, sleep/wake schedule, or feeding/activity behavior can affect the circadian function of the clocks located in the brain and peripheral tissues. These alterations have been associated with impaired glucose tolerance and type 2 diabetes. Animal models with molecular manipulation of clock genes and genetic studies in humans also support these links. It has been demonstrated that the endocrine pancreas has an intrinsic self-sustained clock, and recent studies have revealed an important role of clock genes in pancreatic ? cells, glucose homeostasis, and diabetes. |Animals [MESH] |CLOCK Proteins/*genetics/metabolism [MESH] |Circadian Rhythm [MESH] |Diabetes Mellitus, Type 2/*genetics/metabolism [MESH] |Disease Models, Animal [MESH] |Gene Expression Regulation [MESH] |Homeostasis [MESH] |Humans [MESH] |Insulin Secretion [MESH] |Insulin-Secreting Cells/metabolism [MESH] |Insulin/metabolism [MESH]Clock genes, pancreatic function, and diabetes (epmc).pdf DeepDyve Pubget Overpricing