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2014 ; 93
(27
): e131
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Clinicopathological features of gallbladder papillary adenocarcinoma
#MMPMID25501049
Wan X
; Zhang H
; Chen C
; Yang X
; Wang A
; Zhu C
; Fu L
; Miao R
; He L
; Yang H
; Zhao H
; Sang X
Medicine (Baltimore)
2014[Dec]; 93
(27
): e131
PMID25501049
show ga
Although patients with gallbladder papillary adenocarcinoma (GBPA) appear to have
better prognoses than patients with other pathological subtypes of gallbladder
carcinoma (GBC), the clinicopathological features and outcomes of GBPA have not
been fully explored. This study therefore analyzed the clinicopathological
characteristics and outcomes of GBPA.This study included 16 patients with GBPA
and 101 with gallbladder adenocarcinoma (GBA) not otherwise specified (NOS), all
diagnosed pathologically after surgical resection. Clinicopathological and
survival data were retrospectively collected and compared. Fever was
significantly more common in GBPA (7/16 vs 10/101; P = 0.000). Serum carbohydrate
antigen 19-9 level was increased in 1 of 9 patients with GBPA and 39 of 76 with
GBA (P = 0.022). More patients with GBPA underwent curative resection (15/16 vs
54/101; P = 0.009). Pathologically, patients with GBPA were at much earlier tumor
(T) (4 in situ, 8 T1; P = 0.000) and Tumor, Node, Metastases (TNM) stages (P =
0.000). The overall 1-, 3-, and 5-year survival rates were significantly higher
in patients with GBPA (100%, 76.9%, and 76.9%, respectively), than in patients
with GBA (72.2%, 38.8%, and 31.0%, respectively; P = 0.001). Preoperative
jaundice (odds ratio 7.69; 95% confidence interval, 1.53-38.76; P = 0.013) was a
significant prognostic factor in patients with GBA, but was no longer significant
when the patients with GBA and GBPA were pooled together. The clinicopathological
features of patients with GBPA differed from those in patients with GBA (not
otherwise specified). Pooling of patients may mask prognostic factors in each
group.