Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26722599
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Int+J+Clin+Exp+Pathol
2015 ; 8
(10
): 13711-8
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Clinicopathological features of Kaposiform hemangioendothelioma
#MMPMID26722599
Liu Q
; Jiang L
; Wu D
; Kan Y
; Fu F
; Zhang D
; Gong Y
; Wang Y
; Dong C
; Kong L
Int J Clin Exp Pathol
2015[]; 8
(10
): 13711-8
PMID26722599
show ga
Kaposiform hemangioendothelioma (KHE), an intermediate tumor of endothelial
origin in childhood, is often associated with Kasabach-Merritt phenomenon (KMP).
In this study, 22 cases of KHE were immunochemically studied for CD31, CD34, ERG,
smooth muscle actin (SMA), D240, GLUT1 and Ki67. The patients (15 males and 7
females) ranged in age from 13 days to 7 years (median, 2 mo). Lesion developed
on the extremities/joint (12 cases), chest/abdominal wall (6 cases), head/neck (4
cases), and presented both superficial and deep soft tissue. The superficial
change was commonly enlarging cutaneous lesion with ill-defined red to purple
indurated plaque. 15 of the 22 cases (68%) developed KMP, with consumptive
thrombocytopenia or bleeding complications. Tumors consisted of infiltrating
nodules of fascicles of spindleshaped endothelial cells and slitlike vascular
channels with irregular tumor margins. On immunohistochemistry (IHC), endothelial
cells were diffusely positive for CD34, CD31 and ERG but negative for GLUT1, and
the peripheral area of proliferative capillaries were markedly positive for D240.
Adjuvant medical therapy and sclerotherapy were prepared for the tumor and the
associated KMP, and then all patients were treated by complete surgical excision.
Follow-up information was available in 22 patients (8 to 26 months, mean 15 mo),
and indicated that 1 died of multiple organ failure and 21 were alive without
residual disease. In conclusion, our results suggest that KHE can occur in the
embryonic period, and patients with KMP often have earlier onset time and larger
lesional size. KHE patients given with adjuvant corticosteroids and urea
injection and complete resection rarely relapse.
free
free
free
