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2008 ; 141
(ä): 87-113
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Clinical uses of microarrays in cancer research
#MMPMID18453086
Virtanen C
; Woodgett J
Methods Mol Med
2008[]; 141
(ä): 87-113
PMID18453086
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Perturbations in genes play a key role in the pathogenesis of cancer.
Microarray-based technology is an ideal way in which to study the effects and
interactions of multiple genes in cancer. There are many technologic challenges
in running a microarray study, including annotation of genes likely to be
involved, designing the appropriate experiment, and ensuring adequate quality
assurance steps are implemented. Once data are normalized, they need to be
analyzed; and for this, there are numerous software packages and approaches.