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2016 ; 13
(3
): 360-372
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gab.com Text
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English Wikipedia
Clinical management of myelodysplastic syndrome/myeloproliferative neoplasm
overlap syndromes
#MMPMID27807503
Clara JA
; Sallman DA
; Padron E
Cancer Biol Med
2016[Sep]; 13
(3
): 360-372
PMID27807503
show ga
The myelodysplastic/myeloproliferative neoplasms (MDS/MPNs) are a unique group of
hematologic malignancies characterized by concomitant myelodysplastic and
myeloproliferative features. According to the 2008 WHO classification, the
category includes atypical chronic myeloid leukemia (aCML), chronic
myelomonocytic leukemia (CMML), juvenile myelomonocytic leukemia (JMML),
MDS/MPN-unclassifiable (MDS/MPN-U), and the provisional entity refractory anemia
with ring sideroblasts and thrombocytosis (RARS-T). Although diagnosis currently
remains based on clinicopathologic features, the incorporation of next-generation
platforms has allowed for the recent molecular characterization of these diseases
which has revealed unique and complex mutational profiles that support their
distinct biology and is anticipated to soon play an integral role in diagnosis,
prognostication, and treatment. Future goals of research should include the
development of disease-modifying therapies, and further genetic understanding of
the category will likely form the foundation of these efforts.