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10.1093/qjmed/hcv181 http://scihub22266oqcxt.onion/10.1093/qjmed/hcv181 C4900488!4900488 !26428335     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26428335 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       QJM 2016 ; 109 (6 ): 367-72 Nephropedia Template TP {{tp|p=26428335 |t=2016. Clinical development of cancer therapeutics that target metabolism |pdf=|usr=}}{{26428335 }} gab.com Text Clinical development of cancer therapeutics that target metabolism JO: QJM http://www.kidney.de/pget.php?&tw=1&pmid=26428335 #FOAvip Glucose and glutamine metabolism in cancer cells are markedly elevated relative to non-transformed normal cells. This metabolic reprogramming enables the production of adenosine triphosphate and the anabolic precursors needed for survival, growth and motility. The recent observations that mutant oncogenic proteins and the loss of tumor suppressors activate key metabolic enzymes suggest that selective inhibition of these enzymes may yield effective cancer therapeutics with acceptable toxicities. In support of this concept, pre-clinical studies of small molecule antagonists of several metabolic enzymes in tumor-bearing mice have demonstrated reasonable therapeutic indices. We will review the rationale for targeting metabolic enzymes as a strategy to treat cancer and will detail the results of several recent clinical trials of metabolic inhibitors in advanced cancer patients. Twit Text FOAVip Clinical development of cancer therapeutics that target metabolism ????QJM http://www.kidney.de/pget.php?&tw=1&pmid=26428335 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26428335 #FOAvip English Wikipedia <ref>{{Cite pmid|26428335 }}</ref> Clinical development of cancer therapeutics that target metabolism #MMPMID26428335 Clem BF ; O'Neal J ; Klarer AC ; Telang S ; Chesney J QJM 2016[Jun]; 109 (6 ): 367-72 PMID26428335 show ga Glucose and glutamine metabolism in cancer cells are markedly elevated relative to non-transformed normal cells. This metabolic reprogramming enables the production of adenosine triphosphate and the anabolic precursors needed for survival, growth and motility. The recent observations that mutant oncogenic proteins and the loss of tumor suppressors activate key metabolic enzymes suggest that selective inhibition of these enzymes may yield effective cancer therapeutics with acceptable toxicities. In support of this concept, pre-clinical studies of small molecule antagonists of several metabolic enzymes in tumor-bearing mice have demonstrated reasonable therapeutic indices. We will review the rationale for targeting metabolic enzymes as a strategy to treat cancer and will detail the results of several recent clinical trials of metabolic inhibitors in advanced cancer patients. |*Drug Design [MESH] |*Molecular Targeted Therapy/trends [MESH] |Antineoplastic Agents/*pharmacology/*therapeutic use [MESH] |Biomarkers, Tumor/metabolism [MESH] |Cell Proliferation/drug effects [MESH] |Cell Transformation, Neoplastic/drug effects [MESH] |Energy Metabolism/drug effects [MESH] |Gene Expression Regulation, Neoplastic/drug effects [MESH] |Humans [MESH] |Neoplasms/*drug therapy/enzymology/*metabolism [MESH] |Oxidative Phosphorylation/drug effects [MESH]Clinical development of cancer therapeutics that target metabolism (epmc).pdf DeepDyve Pubget Overpricing