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2016 ; 2
(ä): 12
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Clinical applications of fundus autofluorescence in retinal disease
#MMPMID27847630
Yung M
; Klufas MA
; Sarraf D
Int J Retina Vitreous
2016[]; 2
(ä): 12
PMID27847630
show ga
Fundus autofluorescence (FAF) is a non-invasive retinal imaging modality used in
clinical practice to provide a density map of lipofuscin, the predominant ocular
fluorophore, in the retinal pigment epithelium. Multiple commercially available
imaging systems, including the fundus camera, the confocal scanning laser
ophthalmoscope, and the ultra-widefield imaging device, are available to the
clinician. Each offers unique advantages for evaluating various retinal diseases.
The clinical applications of FAF continue to expand. It is now an essential tool
for evaluating age related macular degeneration, macular dystrophies, retinitis
pigmentosa, white dot syndromes, retinal drug toxicities, and various other
retinal disorders. FAF may detect abnormalities beyond those detected on
funduscopic exam, fluorescein angiography, or optical coherence tomography, and
can be used to elucidate disease pathogenesis, form genotype-phenotype
correlations, diagnose and monitor disease, and evaluate novel therapies. Given
its ease of use, non-invasive nature, and value in characterizing retinal
disease, FAF enjoys increasing clinical relevance. This review summarizes common
ocular fluorophores, imaging modalities, and FAF findings for a wide spectrum of
retinal disorders.