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10.1007/s11906-018-0826-6 http://scihub22266oqcxt.onion/10.1007/s11906-018-0826-6 C5893690!5893690 !29637415     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29637415 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Curr+Hypertens+Rep 2018 ; 20 (4 ): 31 Nephropedia Template TP {{tp|p=29637415 |t=2018. Clinical and Molecular Features of Thiazide-Induced Hyponatremia |pdf=|usr=}}{{29637415 }} gab.com Text Clinical and Molecular Features of Thiazide-Induced Hyponatremia JO: Curr Hypertens Rep http://www.kidney.de/pget.php?&tw=1&pmid=29637415 #FOAvip PURPOSE OF REVIEW: Hypertension affects more than 30% of the world's adult population and thiazide (and thiazide-like) diuretics are amongst the most widely used, effective, and least costly treatments available, with all-cause mortality benefits equivalent to angiotensin-converting enzyme inhibitors or calcium channel antagonists. A minority of patients develop thiazide-induced hyponatremia (TIH) and this is largely unpredictable at the point of thiazide prescription. In some cases, TIH can cause debilitating symptoms and require hospital admission. Although TIH affects only a minority of patients exposed to thiazides, the high prevalence of hypertension leads to TIH being the most common cause of drug-induced hyponatremia requiring hospital admission in the UK. This review examines current clinical and scientific understanding of TIH. Consideration is given to demographic associations, limitations of current electrolyte monitoring regimens, clinical presentation, the phenotype evident on routine clinical blood and urine tests as well as more extensive analyses of blood and urine in research settings, recent genetic associations with TIH, and thoughts on management of the condition. RECENT FINDINGS: Recent genetic and phenotyping analysis has suggested that prostaglandin E2 pathways in the collecting duct may have a role in the development of TIH in a subgroup of patients. Greater understanding of the molecular pathophysiology of TIH raises the prospect of pre-prescription TIH risk profiling and may offer novel insights into how TIH may be avoided, prevented and treated. The rising prevalence of hypertension and the widespread use of thiazides mean that further understanding of TIH will continue to be a pressing issue for patients, physicians, and scientists alike for the foreseeable future. Twit Text FOAVip Clinical and Molecular Features of Thiazide-Induced Hyponatremia ????Curr Hypertens Rep http://www.kidney.de/pget.php?&tw=1&pmid=29637415 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29637415 #FOAvip English Wikipedia <ref>{{Cite pmid|29637415 }}</ref> Clinical and Molecular Features of Thiazide-Induced Hyponatremia #MMPMID29637415 Nadal J ; Channavajjhala SK ; Jia W ; Clayton J ; Hall IP ; Glover M Curr Hypertens Rep 2018[Apr]; 20 (4 ): 31 PMID29637415 show ga PURPOSE OF REVIEW: Hypertension affects more than 30% of the world's adult population and thiazide (and thiazide-like) diuretics are amongst the most widely used, effective, and least costly treatments available, with all-cause mortality benefits equivalent to angiotensin-converting enzyme inhibitors or calcium channel antagonists. A minority of patients develop thiazide-induced hyponatremia (TIH) and this is largely unpredictable at the point of thiazide prescription. In some cases, TIH can cause debilitating symptoms and require hospital admission. Although TIH affects only a minority of patients exposed to thiazides, the high prevalence of hypertension leads to TIH being the most common cause of drug-induced hyponatremia requiring hospital admission in the UK. This review examines current clinical and scientific understanding of TIH. Consideration is given to demographic associations, limitations of current electrolyte monitoring regimens, clinical presentation, the phenotype evident on routine clinical blood and urine tests as well as more extensive analyses of blood and urine in research settings, recent genetic associations with TIH, and thoughts on management of the condition. RECENT FINDINGS: Recent genetic and phenotyping analysis has suggested that prostaglandin E2 pathways in the collecting duct may have a role in the development of TIH in a subgroup of patients. Greater understanding of the molecular pathophysiology of TIH raises the prospect of pre-prescription TIH risk profiling and may offer novel insights into how TIH may be avoided, prevented and treated. The rising prevalence of hypertension and the widespread use of thiazides mean that further understanding of TIH will continue to be a pressing issue for patients, physicians, and scientists alike for the foreseeable future. |Diuretics/*adverse effects/therapeutic use [MESH] |Humans [MESH] |Hypertension/diet therapy/*drug therapy/physiopathology [MESH] |Hyponatremia/*chemically induced/diagnosis/*genetics/therapy [MESH]Clinical and Molecular Features of Thiazide-Induced Hyponatremia (epmc).pdf DeepDyve Pubget Overpricing