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2016 ; 28
(2
): 152-8
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Clinical and Histopathological Investigation of Seborrheic Keratosis
#MMPMID27081260
Roh NK
; Hahn HJ
; Lee YW
; Choe YB
; Ahn KJ
Ann Dermatol
2016[Apr]; 28
(2
): 152-8
PMID27081260
show ga
BACKGROUND: Seborrheic keratosis (SK) is one of the most common epidermal tumors
of the skin. However, only a few large-scale clinicohistopathological
investigations have been conducted on SK or on the possible correlation between
histopathological SK subtype and location. OBJECTIVE: The aim of this study was
to analyze the clinical and histopathological features of a relatively large
number of cases of diagnosed SK. METHODS: Two hundred and seventy-one pathology
slides of skin tissue from patients with clinically diagnosed SK and 206 cases of
biopsy-proven SK were analyzed. The biopsy-proven cases of SK were assessed for
histopathological subclassification. The demographic, clinical, and
histopathological data of the patients were collected for analysis of associated
factors. RESULTS: The most frequent histopathological subtype was the acanthotic
type, followed by mixed, hyperkeratotic, melanoacanthoma, clonal, irritated, and
adenoid types; an unexpectedly high percentage (9.2%) of the melanoacanthoma
variant was observed. The adenoid type was more common in sun-exposed sites than
in sun-protected sites (p=0.028). Premalignant and malignant entities together
represented almost one-quarter (24.2%) of the clinicopathological mismatch cases
(i.e., mismatch between the clinical and histopathological diagnoses). Regarding
the location of SK development, the frequency of mismatch for the sun-exposed
areas was significantly higher than that for sun-protected areas (p=0.043).
CONCLUSION: The adenoid type was more common in sun-exposed sites. Biopsy
sampling should be performed for lesions situated in sun-exposed areas to exclude
other premalignant or malignant diseases.