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2016 ; 48
(1
): 1-11
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Clinical Usefulness of Arbekacin
#MMPMID27104010
Lee JH
; Lee CS
Infect Chemother
2016[Mar]; 48
(1
): 1-11
PMID27104010
show ga
Arbekacin is a broad-spectrum aminoglycoside used to treat methicillin-resistant
Staphylococcus aureus (MRSA). Arbekacin has antibacterial activities against
high-level gentamicin-resistant Enterococci, multidrug-resistant Pseudomonas
aeruginosa, and Acinetobacter baumannii et al. Here, we reviewed in vitro data on
arbekacin in Staphylococci and Gram-negative microorganisms. We also reviewed
clinical studies for clinical efficacy and microbiologic efficacy data in
patients with identified MRSA and suspected MRSA infections. The overall clinical
efficacy ranged from 66.7% to 89.7%. The microbiologic efficacy rate ranged from
46.2% to 83%. In comparative studies between arbekacin and glycopeptides,
arbekacin was similar to other glycopeptides with respect to clinical and
microbiological efficacy rates. Combination trials with other antibiotics suggest
that arbekacin will be a promising strategy to control Enterococcus spp.
multi-drug resistant P. aeruginosa. The major adverse reaction was
nephrotoxicity/hepatotoxicity, but patients recovered from most adverse reactions
without any severe complications. Based on these results, arbekacin could be a
good alternative to vancomycin/teicoplanin in MRSA treatment. Finally,
therapeutic drug monitoring is recommended to maximize clinical efficacy and
decrease nephrotoxicity.