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10.1016/j.tips.2016.10.009

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pmid27876286
      Trends+Pharmacol+Sci 2017 ; 38 (1 ): 4-7
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  • Clinical Trials in a Dish #MMPMID27876286
  • Strauss DG ; Blinova K
  • Trends Pharmacol Sci 2017[Jan]; 38 (1 ): 4-7 PMID27876286 show ga
  • Clinical trials 'in a dish' involve testing medical therapies for safety or effectiveness in the laboratory with human tissue. This has become possible owing to recent biotechnology advances including induced pluripotent stem cells, organs-on-a-chip, and whole-genome sequencing. We provide here an overview of the landscape and highlight steps the FDA is taking to advance the science of clinical trials in a dish and to support the development and validation of new regulatory paradigms to assess drug safety using these new technologies.
  • |*Clinical Trials as Topic [MESH]
  • |Humans [MESH]
  • |Induced Pluripotent Stem Cells/cytology/drug effects [MESH]
  • |Precision Medicine [MESH]
  • |United States [MESH]


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