Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26308064
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26308064
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Clin+Med
2015 ; 4
(9
): 1668-87
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Clinical Potential of microRNA-7 in Cancer
#MMPMID26308064
Horsham JL
; Kalinowski FC
; Epis MR
; Ganda C
; Brown RA
; Leedman PJ
J Clin Med
2015[Aug]; 4
(9
): 1668-87
PMID26308064
show ga
microRNAs (miRNAs) are a family of short, non-coding RNA molecules that drive a
complex network of post-transcriptional gene regulation by enhancing target mRNA
decay and/or inhibiting protein synthesis from mRNA transcripts. They regulate
genes involved in key aspects of normal cell growth, development and the
maintenance of body homeostasis and have been closely linked to the development
and progression of human disease, in particular cancer. Over recent years there
has been much interest regarding their potential as biomarkers and as therapeutic
agents or targets. microRNA-7 (miR-7) is a 23 nucleotide (nt) miRNA known
primarily to act as a tumour suppressor. miR-7 directly inhibits a number of
oncogenic targets and impedes various aspects of cancer progression in vitro and
in vivo, however, some studies have also implicated miR-7 in oncogenic roles.
This review summarises the role of miR-7 in cancer, its potential in miRNA-based
replacement therapy and its capacity as both a diagnostic and prognostic
biomarker.