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2015 ; 7
(9
): 4929-44
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Clinical Implications of Antiviral Resistance in Influenza
#MMPMID26389935
Li TC
; Chan MC
; Lee N
Viruses
2015[Sep]; 7
(9
): 4929-44
PMID26389935
show ga
Influenza is a major cause of severe respiratory infections leading to excessive
hospitalizations and deaths globally; annual epidemics, pandemics, and
sporadic/endemic avian virus infections occur as a result of rapid, continuous
evolution of influenza viruses. Emergence of antiviral resistance is of great
clinical and public health concern. Currently available antiviral treatments
include four neuraminidase inhibitors (oseltamivir, zanamivir, peramivir,
laninamivir), M2-inibitors (amantadine, rimantadine), and a polymerase inhibitor
(favipiravir). In this review, we focus on resistance issues related to the use
of neuraminidase inhibitors (NAIs). Data on primary resistance, as well as
secondary resistance related to NAI exposure will be presented. Their clinical
implications, detection, and novel therapeutic options undergoing clinical trials
are discussed.
|*Drug Resistance, Viral
[MESH]
|Antiviral Agents/*pharmacology/therapeutic use
[MESH]