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2015 ; 94
(36
): e1285
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Clinical Features and Outcomes of Pasteurella multocida Infection
#MMPMID26356688
Giordano A
; Dincman T
; Clyburn BE
; Steed LL
; Rockey DC
Medicine (Baltimore)
2015[Sep]; 94
(36
): e1285
PMID26356688
show ga
Pasteurella multocida, a zoonotic infectious organism, has most often been
described in patients after an animal bite. Here, we characterize the clinical
features and outcomes of P multocida infection in a large cohort of patients
according to the presence or absence of an animal bite.We retrospectively
searched MUSC's laboratory information system for all patients with positive P
multocida cultures from 2000 to 2014. Extensive data were abstracted, including
clinical and outcome data. The Charlson comorbidity index (CCI) was used to
assess comorbidities among patients.We identified 44 patients with P multocida
infections, including 25 with an animal bite. The average age was 64 years and
the majority of patients were women (N?=?30). There was no difference in age and
sex distribution among those with and without a bite (P?=?0.38 and 0.75,
respectively). A CCI ?1 was significantly associated with the absence of a bite
(P?=?0.006). Patients presenting without a bite were more frequently bacteremic
(37% vs 4%, respectively, P?=?0.001), and were hospitalized more often (84% vs
44%, respectively, P?=?0.012). Of the 8 patients who required intensive care unit
(ICU)-based care, 7 were non-bite-related. There were 4 deaths, all occurring in
patients not bitten.P multocida infections not associated with an animal bite
were often associated with bacteremia, severe comorbidity(ies),
immune-incompetent states, the need for ICU management, and were associated with
substantial mortality.