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2018 ; 24
(ä): 2210-2217
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Clinical Effects of "Selective Drug" Regulating Vagus Nerve Signal Pathway in
Vagally-Mediated Atrial Fibrillation
#MMPMID29652036
Lou X
; Lu Y
; Tang B
; Zhou X
Med Sci Monit
2018[Apr]; 24
(ä): 2210-2217
PMID29652036
show ga
BACKGROUND The cardiac autonomic nervous system plays a crucial role in genesis
and development of atrial fibrillation (AF) through the G protein signal
transduction pathway. Therefore, intervening in the G protein signal transduction
pathway may be a new "selective drug" method to regulate autonomic nerve activity
to prevent vagally-mediated AF. MATERIAL AND METHODS Seventeen adult beagles were
randomized into 3 groups: shame-operation control group (group A, n=5), empty
vector gene control group (group B, n=6), and G?i2ctp gene experimental group
(group C, n=6). Group A was injected with normal saline into the anterior atrial
wall, and group B and group C animals were injected with recombinant adenovirus
with empty vector or G?i2ctp vector in the same region. AF was induced by the
method of rapid atrial pacing in groups B and C. To determine the clinical effect
of vagal modulation, the effective refractory periods (ERP) and field action
potential duration (FAPD) were evaluated by electrophysiological study. The
expression levels of tyrosine hydroxylase (TH) and choline acetyl transferase
(CHAT) in different parts were determined with immunohistochemistry. RESULTS
After successful Gai2ctp gene transfer, in group B, the ERP and FAPD
significantly decreased (P<0.05), and TH and CHAT expression observably increased
(P<0.05), while those differences were absent between groups A and C (P>0.05).
CONCLUSIONS Recombinant adenovirus-mediated overexpression of G?i2ctp in canine
myocardial cells can interfere with the activity of the vagus nerve, reverse the
development and progression of electrical remodeling, and reduce the incidence of
AF.
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