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10.1016/j.chembiol.2014.09.002 http://scihub22266oqcxt.onion/10.1016/j.chembiol.2014.09.002 C4331201!4331201 !25237856     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25237856 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Chem+Biol 2014 ; 21 (9 ): 1075-101 Nephropedia Template TP {{tp|p=25237856 |t=2014. Click chemistry in complex mixtures: bioorthogonal bioconjugation |pdf=|usr=}}{{25237856 }} gab.com Text Click chemistry in complex mixtures: bioorthogonal bioconjugation JO: Chem Biol http://www.kidney.de/pget.php?&tw=1&pmid=25237856 #FOAvip The selective chemical modification of biological molecules drives a good portion of modern drug development and fundamental biological research. While a few early examples of reactions that engage amine and thiol groups on proteins helped establish the value of such processes, the development of reactions that avoid most biological molecules so as to achieve selectivity in desired bond-forming events has revolutionized the field. We provide an update on recent developments in bioorthogonal chemistry that highlights key advances in reaction rates, biocompatibility, and applications. While not exhaustive, we hope this summary allows the reader to appreciate the rich continuing development of good chemistry that operates in the biological setting. Twit Text FOAVip Click chemistry in complex mixtures: bioorthogonal bioconjugation ????Chem Biol http://www.kidney.de/pget.php?&tw=1&pmid=25237856 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25237856 #FOAvip English Wikipedia <ref>{{Cite pmid|25237856 }}</ref> Click chemistry in complex mixtures: bioorthogonal bioconjugation #MMPMID25237856 McKay CS ; Finn MG Chem Biol 2014[Sep]; 21 (9 ): 1075-101 PMID25237856 show ga The selective chemical modification of biological molecules drives a good portion of modern drug development and fundamental biological research. While a few early examples of reactions that engage amine and thiol groups on proteins helped establish the value of such processes, the development of reactions that avoid most biological molecules so as to achieve selectivity in desired bond-forming events has revolutionized the field. We provide an update on recent developments in bioorthogonal chemistry that highlights key advances in reaction rates, biocompatibility, and applications. While not exhaustive, we hope this summary allows the reader to appreciate the rich continuing development of good chemistry that operates in the biological setting. |*Click Chemistry [MESH] |Aldehydes/chemistry [MESH] |Amines/chemistry [MESH] |Amino Acids/chemistry [MESH] |Hydroxides/chemistry [MESH] |Ketones/chemistry [MESH] |Organometallic Compounds/chemistry [MESH] |Prodrugs/chemistry/metabolism [MESH]Click chemistry in complex mixtures: bioorthogonal bioconjugation (epmc).pdf DeepDyve Pubget Overpricing