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10.1016/j.devcel.2017.02.016

http://scihub22266oqcxt.onion/10.1016/j.devcel.2017.02.016
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C5395098!5395098 !28399394
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suck abstract from ncbi


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pmid28399394
      Dev+Cell 2017 ; 41 (1 ): 10-22
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  • Cleaning House: Selective Autophagy of Organelles #MMPMID28399394
  • Anding AL ; Baehrecke EH
  • Dev Cell 2017[Apr]; 41 (1 ): 10-22 PMID28399394 show ga
  • The selective clearance of organelles by autophagy is critical for the regulation of cellular homeostasis in organisms from yeast to humans. Removal of damaged organelles clears the cell of potentially toxic byproducts and enables reuse of organelle components for bioenergetics. Thus, defects in organelle clearance may be detrimental to the health of the cells, contributing to cancer, neurodegeneration, and inflammatory diseases. Organelle-specific autophagy can clear mitochondria, peroxisomes, lysosomes, ER, chloroplasts, and the nucleus. Here, we review our understanding of the mechanisms that regulate the clearance of organelles by autophagy and highlight gaps in our knowledge of these processes.
  • |*Autophagy [MESH]
  • |Animals [MESH]
  • |Humans [MESH]
  • |Mitophagy [MESH]
  • |Models, Biological [MESH]


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