Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28399394
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Dev+Cell
2017 ; 41
(1
): 10-22
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Cleaning House: Selective Autophagy of Organelles
#MMPMID28399394
Anding AL
; Baehrecke EH
Dev Cell
2017[Apr]; 41
(1
): 10-22
PMID28399394
show ga
The selective clearance of organelles by autophagy is critical for the regulation
of cellular homeostasis in organisms from yeast to humans. Removal of damaged
organelles clears the cell of potentially toxic byproducts and enables reuse of
organelle components for bioenergetics. Thus, defects in organelle clearance may
be detrimental to the health of the cells, contributing to cancer,
neurodegeneration, and inflammatory diseases. Organelle-specific autophagy can
clear mitochondria, peroxisomes, lysosomes, ER, chloroplasts, and the nucleus.
Here, we review our understanding of the mechanisms that regulate the clearance
of organelles by autophagy and highlight gaps in our knowledge of these
processes.