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10.1016/j.semcdb.2015.04.009 http://scihub22266oqcxt.onion/10.1016/j.semcdb.2015.04.009 C4562902!4562902 !25951797     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25951797 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Semin+Cell+Dev+Biol 2015 ; 42 (ä): 47-57 Nephropedia Template TP {{tp|p=25951797 |t=2015. Claudins: Gatekeepers of lung epithelial function |pdf=|usr=}}{{25951797 }} gab.com Text Claudins: Gatekeepers of lung epithelial function JO: Semin Cell Dev Biol http://www.kidney.de/pget.php?&tw=1&pmid=25951797 #FOAvip The lung must maintain a proper barrier between airspaces and fluid filled tissues in order to maintain lung fluid balance. Central to maintaining lung fluid balance are epithelial cells which create a barrier to water and solutes. The barrier function of these cells is mainly provided by tight junction proteins known as claudins. Epithelial barrier function varies depending on the different needs within the segments of the respiratory tree. In the lower airways, fluid is required to maintain mucociliary clearance, whereas in the terminal alveolar airspaces a thin layer of surfactant enriched fluid lowers surface tension to prevent airspace collapse and is critical for gas exchange. As the epithelial cells within the segments of the respiratory tree differ, the composition of claudins found in these epithelial cells is also different. Among these differences is claudin-18 which is uniquely expressed by the alveolar epithelial cells. Other claudins, notably claudin-4 and claudin-7, are more ubiquitously expressed throughout the respiratory epithelium. Claudin-5 is expressed by both pulmonary epithelial and endothelial cells. Based on in vitro and in vivo model systems and histologic analysis of lungs from human patients, roles for specific claudins in maintaining barrier function and protecting the lung from the effects of acute injury and disease are being identified. One surprising finding is that claudin-18 and claudin-4 control lung cell phenotype and inflammation beyond simply maintaining a selective paracellular permeability barrier. This suggests claudins have more nuanced roles for the control of airway and alveolar physiology in the healthy and diseased lung. Twit Text FOAVip Claudins: Gatekeepers of lung epithelial function ????Semin Cell Dev Biol http://www.kidney.de/pget.php?&tw=1&pmid=25951797 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25951797 #FOAvip English Wikipedia <ref>{{Cite pmid|25951797 }}</ref> Claudins: Gatekeepers of lung epithelial function #MMPMID25951797 Schlingmann B ; Molina SA ; Koval M Semin Cell Dev Biol 2015[Jun]; 42 (ä): 47-57 PMID25951797 show ga The lung must maintain a proper barrier between airspaces and fluid filled tissues in order to maintain lung fluid balance. Central to maintaining lung fluid balance are epithelial cells which create a barrier to water and solutes. The barrier function of these cells is mainly provided by tight junction proteins known as claudins. Epithelial barrier function varies depending on the different needs within the segments of the respiratory tree. In the lower airways, fluid is required to maintain mucociliary clearance, whereas in the terminal alveolar airspaces a thin layer of surfactant enriched fluid lowers surface tension to prevent airspace collapse and is critical for gas exchange. As the epithelial cells within the segments of the respiratory tree differ, the composition of claudins found in these epithelial cells is also different. Among these differences is claudin-18 which is uniquely expressed by the alveolar epithelial cells. Other claudins, notably claudin-4 and claudin-7, are more ubiquitously expressed throughout the respiratory epithelium. Claudin-5 is expressed by both pulmonary epithelial and endothelial cells. Based on in vitro and in vivo model systems and histologic analysis of lungs from human patients, roles for specific claudins in maintaining barrier function and protecting the lung from the effects of acute injury and disease are being identified. One surprising finding is that claudin-18 and claudin-4 control lung cell phenotype and inflammation beyond simply maintaining a selective paracellular permeability barrier. This suggests claudins have more nuanced roles for the control of airway and alveolar physiology in the healthy and diseased lung. |Animals [MESH] |Claudins/*metabolism [MESH] |Cystic Fibrosis/pathology/physiopathology [MESH] |Humans [MESH] |Lung/*metabolism [MESH] |Respiratory Mucosa/cytology/*metabolism [MESH]Claudins: Gatekeepers of lung epithelial function (epmc).pdf DeepDyve Pubget Overpricing