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2014 ; 13
(ä): 922-37
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Classification of oxidative stress based on its intensity
#MMPMID26417312
Lushchak VI
EXCLI J
2014[]; 13
(ä): 922-37
PMID26417312
show ga
In living organisms production of reactive oxygen species (ROS) is
counterbalanced by their elimination and/or prevention of formation which in
concert can typically maintain a steady-state (stationary) ROS level. However,
this balance may be disturbed and lead to elevated ROS levels called oxidative
stress. To our best knowledge, there is no broadly acceptable system of
classification of oxidative stress based on its intensity due to which proposed
here system may be helpful for interpretation of experimental data. Oxidative
stress field is the hot topic in biology and, to date, many details related to
ROS-induced damage to cellular components, ROS-based signaling, cellular
responses and adaptation have been disclosed. However, it is common situation
when researchers experience substantial difficulties in the correct
interpretation of oxidative stress development especially when there is a need to
characterize its intensity. Careful selection of specific biomarkers
(ROS-modified targets) and some system may be helpful here. A classification of
oxidative stress based on its intensity is proposed here. According to this
classification there are four zones of function in the relationship between
"Dose/concentration of inducer" and the measured "Endpoint": I - basal oxidative
stress (BOS); II - low intensity oxidative stress (LOS); III - intermediate
intensity oxidative stress (IOS); IV - high intensity oxidative stress (HOS). The
proposed classification will be helpful to describe experimental data where
oxidative stress is induced and systematize it based on its intensity, but
further studies will be in need to clear discriminate between stress of different
intensity.