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2017 ; 2017
(ä): 8637138
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Classification and Differential Diagnosis of Diabetic Nephropathy
#MMPMID28316995
Qi C
; Mao X
; Zhang Z
; Wu H
J Diabetes Res
2017[]; 2017
(ä): 8637138
PMID28316995
show ga
Diabetic nephropathy (DN) is a major cause of end-stage renal disease throughout
the world in both developed and developing countries. This review briefly
introduces the characteristic pathological changes of DN and Tervaert
pathological classification, which divides DN into four classifications according
to glomerular lesions, along with a separate scoring system for tubular,
interstitial, and vascular lesions. Given the heterogeneity of the renal lesions
and the complex mechanism underlying diabetic nephropathy, Tervaert
classification has both significance and controversies in the guidance of
diagnosis and prognosis. Applications and evaluations using Tervaert
classification and indications for renal biopsy are summarized in this review
according to recent studies. Meanwhile, differential diagnosis with another
nodular glomerulopathy and the situation that a typical DN superimposed with a
nondiabetic renal disease (NDRD) are discussed and concluded in this review.