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2014 ; 5
(4
): 253-60
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Classics in chemical neuroscience: diazepam (valium)
#MMPMID24552479
Calcaterra NE
; Barrow JC
ACS Chem Neurosci
2014[Apr]; 5
(4
): 253-60
PMID24552479
show ga
Diazepam (Valium) is among the most successful drugs from the onset of the
psychopharmacological revolution that began during the 1950s. Efficacious in
treating a wide-spectrum of CNS disorders, including anxiety and epilepsy, it set
the standard for pharmacotherapy in terms of potency, onset of action, and
safety. In this Review, the legacy of diazepam to chemical neuroscience will be
considered along with its synthesis, pharmacology, drug metabolism, adverse
events and dependence, clinical use, and regulatory issues.