Circulating Tumor Cell Isolation and Analysis
#MMPMID27346614
Zhang J
; Chen K
; Fan ZH
Adv Clin Chem
2016[]; 75
(?): 1-31
PMID27346614
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Isolation and analysis of cancer cells from body fluids have significant
implications in diagnosis and therapeutic treatment of cancers. Circulating tumor
cells (CTCs) are cancer cells circulating in the peripheral blood or spreading
iatrogenically into blood vessels, which is an early step in the cascade of
events leading to cancer metastasis. Therefore, CTCs can be used for diagnosing
for therapeutic treatment, prognosing a given anticancer intervention, and
estimating the risk of metastatic relapse. However, isolation of CTCs is a
significant technological challenge due to their rarity and low recovery rate
using traditional purification techniques. Recently microfluidic devices
represent a promising platform for isolating cancer cells with high efficiency in
processing complex cellular fluids, with simplicity, sensitivity, and throughput.
This review summarizes recent methods of CTC isolation and analysis, as well as
their applications in clinical studies.
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