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Circuitry underlying temporally extended spatial working memory
#MMPMID17292627
Geier CF
; Garver KE
; Luna B
Neuroimage
2007[Apr]; 35
(2
): 904-15
PMID17292627
show ga
Extended maintenance delays decrease the accuracy of information stored in
spatial working memory. In order to elucidate the network underlying sustained
spatial working memory, 16 subjects were scanned using fast event-related fMRI as
they performed an oculomotor delayed response task containing trials with "short"
(2.5 s) or "long" (10 s) delay periods. Multiple cortical and subcortical regions
were common to both delay trial types indicating core task regions. Three
patterns of activity were found in a subset of core regions that reflect
underlying processes: maintenance-related (e.g., left FEF, right supramarginal
gyrus (SMG)), response planning-related (e.g., right FEF, SEF), and motor
response-related (e.g., lateral cerebellum (declive)) activation. Several regions
were more active during long than short delay trials, including multiple sites in
DLPFC (BA 9, 46), indicating a circuitry dynamically recruited to support
sustained working memory. Our results suggest that specialized brain processes
support extended periods of working memory.