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10.1152/physiolgenomics.00019.2016 http://scihub22266oqcxt.onion/10.1152/physiolgenomics.00019.2016 C5111880!5111880 !27495157     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27495157 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Physiol+Genomics 2016 ; 48 (9 ): 677-87 Nephropedia Template TP {{tp|p=27495157 |t=2016. Circadian variation of the pancreatic islet transcriptome |pdf=|usr=}}{{27495157 }} gab.com Text Circadian variation of the pancreatic islet transcriptome JO: Physiol Genomics http://www.kidney.de/pget.php?&tw=1&pmid=27495157 #FOAvip Pancreatic islet failure is a characteristic feature of impaired glucose control in diabetes mellitus. Circadian control of islet function is essential for maintaining proper glucose homeostasis. Circadian variations in transcriptional pathways have been described in diverse cell types and shown to be critical for optimization of cellular function in vivo. In the current study, we utilized Short Time Series Expression Miner (STEM) analysis to identify diurnally expressed transcripts and biological pathways from mouse islets isolated at 4 h intervals throughout the 24 h light-dark cycle. STEM analysis identified 19 distinct chronological model profiles, and genes belonging to each profile were subsequently annotated to significantly enriched Kyoto Encyclopedia of Genes and Genomes biological pathways. Several transcriptional pathways essential for proper islet function (e.g., insulin secretion, oxidative phosphorylation), cell survival (e.g., insulin signaling, apoptosis) and cell proliferation (DNA replication, homologous recombination) demonstrated significant time-dependent variations. Notably, KEGG pathway analysis revealed "protein processing in endoplasmic reticulum - mmu04141" as one of the most enriched time-dependent pathways in islets. This study provides unique data set on time-dependent diurnal profiles of islet gene expression and biological pathways, and suggests that diurnal variation of the islet transcriptome is an important feature of islet homeostasis, which should be taken into consideration for optimal experimental design and interpretation of future islet studies. Twit Text FOAVip Circadian variation of the pancreatic islet transcriptome ????Physiol Genomics http://www.kidney.de/pget.php?&tw=1&pmid=27495157 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27495157 #FOAvip English Wikipedia <ref>{{Cite pmid|27495157 }}</ref> Circadian variation of the pancreatic islet transcriptome #MMPMID27495157 Rakshit K ; Qian J ; Ernst J ; Matveyenko AV Physiol Genomics 2016[Sep]; 48 (9 ): 677-87 PMID27495157 show ga Pancreatic islet failure is a characteristic feature of impaired glucose control in diabetes mellitus. Circadian control of islet function is essential for maintaining proper glucose homeostasis. Circadian variations in transcriptional pathways have been described in diverse cell types and shown to be critical for optimization of cellular function in vivo. In the current study, we utilized Short Time Series Expression Miner (STEM) analysis to identify diurnally expressed transcripts and biological pathways from mouse islets isolated at 4 h intervals throughout the 24 h light-dark cycle. STEM analysis identified 19 distinct chronological model profiles, and genes belonging to each profile were subsequently annotated to significantly enriched Kyoto Encyclopedia of Genes and Genomes biological pathways. Several transcriptional pathways essential for proper islet function (e.g., insulin secretion, oxidative phosphorylation), cell survival (e.g., insulin signaling, apoptosis) and cell proliferation (DNA replication, homologous recombination) demonstrated significant time-dependent variations. Notably, KEGG pathway analysis revealed "protein processing in endoplasmic reticulum - mmu04141" as one of the most enriched time-dependent pathways in islets. This study provides unique data set on time-dependent diurnal profiles of islet gene expression and biological pathways, and suggests that diurnal variation of the islet transcriptome is an important feature of islet homeostasis, which should be taken into consideration for optimal experimental design and interpretation of future islet studies. |Animals [MESH] |Blood Glucose/metabolism [MESH] |Cell Proliferation/physiology [MESH] |Circadian Clocks/*physiology [MESH] |Circadian Rhythm/*physiology [MESH] |Gene Expression/physiology [MESH] |Homeostasis/physiology [MESH] |Islets of Langerhans/metabolism/*physiology [MESH] |Male [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Signal Transduction/physiology [MESH]Circadian variation of the pancreatic islet transcriptome (epmc).pdf DeepDyve Pubget Overpricing