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10.4161/cc.9.6.11046 http://scihub22266oqcxt.onion/10.4161/cc.9.6.11046 C5884684!5884684 !20237421     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=20237421 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\20237421 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Cycle 2010 ; 9 (6 ): 1097-103 Nephropedia Template TP {{tp|p=20237421 |t=2010. Circadian rhythms and cancer |pdf=|usr=}}{{20237421 }} gab.com Text Circadian rhythms and cancer JO: Cell Cycle http://www.kidney.de/pget.php?&tw=1&pmid=20237421 #FOAvip The circadian clock is an endogenous time keeping system shared by most organisms. In mammals, a master pacemaker in the hypothalamus orchestrates temporal alignment of behavior and physiology by transmitting daily signals to multiple clocks in peripheral tissues. Disruption of this communication has a profound affect on human health and has been linked to diverse pathogenic conditions, including cancer. At the center of the molecular circadian machinery is a set of clock genes, generating rhythmic oscillations on a cellular level. In the past several years, research from different fields has revealed the complexity and ubiquitous nature of circadian regulation, uncovering intriguing associations between clock components and cellular pathways implicated in tumorigenesis. In this review, we discuss the emerging role of circadian genes in hematological and hormone-related malignancies. These new insights suggest that manipulating circadian biology as a way to fight cancer, as well as, other life threatening diseases is within the realm of possibility. Twit Text FOAVip Circadian rhythms and cancer ????Cell Cycle http://www.kidney.de/pget.php?&tw=1&pmid=20237421 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=20237421 #FOAvip English Wikipedia <ref>{{Cite pmid|20237421 }}</ref> Circadian rhythms and cancer #MMPMID20237421 Gery S ; Koeffler HP Cell Cycle 2010[Mar]; 9 (6 ): 1097-103 PMID20237421 show ga The circadian clock is an endogenous time keeping system shared by most organisms. In mammals, a master pacemaker in the hypothalamus orchestrates temporal alignment of behavior and physiology by transmitting daily signals to multiple clocks in peripheral tissues. Disruption of this communication has a profound affect on human health and has been linked to diverse pathogenic conditions, including cancer. At the center of the molecular circadian machinery is a set of clock genes, generating rhythmic oscillations on a cellular level. In the past several years, research from different fields has revealed the complexity and ubiquitous nature of circadian regulation, uncovering intriguing associations between clock components and cellular pathways implicated in tumorigenesis. In this review, we discuss the emerging role of circadian genes in hematological and hormone-related malignancies. These new insights suggest that manipulating circadian biology as a way to fight cancer, as well as, other life threatening diseases is within the realm of possibility. |Animals [MESH] |Circadian Rhythm/*physiology [MESH] |Disease Models, Animal [MESH] |Hematopoietic System [MESH] |Humans [MESH] |Models, Biological [MESH]Circadian rhythms and cancer (epmc).pdf DeepDyve Pubget Overpricing