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2018 ; 119
(ä): 93-107
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Circadian regulation of renal function
#MMPMID29360554
Johnston JG
; Pollock DM
Free Radic Biol Med
2018[May]; 119
(ä): 93-107
PMID29360554
show ga
The kidneys regulate many vital functions that require precise control throughout
the day. These functions, such as maintaining sodium balance or regulating
arterial pressure, rely on an intrinsic clock mechanism that was commonly
believed to be controlled by the central nervous system. Mounting evidence in
recent years has unveiled previously underappreciated depth of influence by
circadian rhythms and clock genes on renal function, at the molecular and
physiological level, independent of other external factors. The impact of
circadian rhythms in the kidney also affects individuals from a clinical
standpoint, as the loss of rhythmic activity or clock gene expression have been
documented in various cardiovascular diseases. Fortunately, the prognostic value
of examining circadian rhythms may prove useful in determining the progression of
a kidney-related disease, and chronotherapy is a clinical intervention that
requires consideration of circadian and diurnal rhythms in the kidney. In this
review, we discuss evidence of circadian regulation in the kidney from basic and
clinical research in order to provide a foundation on which a great deal of
future research is needed to expand our understanding of circadian relevant
biology.
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