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2014 ; 222
(2
): R75-96
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Circadian regulation of metabolism
#MMPMID24928941
Bailey SM
; Udoh US
; Young ME
J Endocrinol
2014[Aug]; 222
(2
): R75-96
PMID24928941
show ga
In association with sleep-wake and fasting-feeding cycles, organisms experience
dramatic oscillations in energetic demands and nutrient supply. It is therefore
not surprising that various metabolic parameters, ranging from the activity
status of molecular energy sensors to circulating nutrient levels, oscillate in
time-of-day-dependent manners. It has become increasingly clear that rhythms in
metabolic processes are not simply in response to daily environmental/behavioral
influences, but are driven in part by cell autonomous circadian clocks. By
synchronizing the cell with its environment, clocks modulate a host of metabolic
processes in a temporally appropriate manner. The purpose of this article is to
review current understanding of the interplay between circadian clocks and
metabolism, in addition to the pathophysiologic consequences of disruption of
this molecular mechanism, in terms of cardiometabolic disease development.
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