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2016 ; 8
(ä): 163-80
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Circadian regulation of metabolic homeostasis: causes and consequences
#MMPMID27313482
McGinnis GR
; Young ME
Nat Sci Sleep
2016[]; 8
(ä): 163-80
PMID27313482
show ga
Robust circadian rhythms in metabolic processes have been described in both
humans and animal models, at the whole body, individual organ, and even cellular
level. Classically, these time-of-day-dependent rhythms have been considered
secondary to fluctuations in energy/nutrient supply/demand associated with
feeding/fasting and wake/sleep cycles. Renewed interest in this field has been
fueled by studies revealing that these rhythms are driven, at least in part, by
intrinsic mechanisms and that disruption of metabolic synchrony invariably
increases the risk of cardiometabolic disease. The objectives of this paper are
to provide a comprehensive review regarding rhythms in glucose, lipid, and
protein/amino acid metabolism, the relative influence of extrinsic (eg,
neurohumoral factors) versus intrinsic (eg, cell autonomous circadian clocks)
mediators, the physiologic roles of these rhythms in terms of daily fluctuations
in nutrient availability and activity status, as well as the pathologic
consequences of dyssynchrony.