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10.1210/er.2015-1007 http://scihub22266oqcxt.onion/10.1210/er.2015-1007 C4446517!4446517 !25927923     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25927923 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25927923 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Endocr+Rev 2015 ; 36 (3 ): 289-304 Nephropedia Template TP {{tp|p=25927923 |t=2015. Circadian metabolism in the light of evolution |pdf=|usr=}}{{25927923 }} gab.com Text Circadian metabolism in the light of evolution JO: Endocr Rev http://www.kidney.de/pget.php?&tw=1&pmid=25927923 #FOAvip Circadian rhythm, or daily oscillation, of behaviors and biological processes is a fundamental feature of mammalian physiology that has developed over hundreds of thousands of years under the continuous evolutionary pressure of energy conservation and efficiency. Evolution has fine-tuned the body's clock to anticipate and respond to numerous environmental cues in order to maintain homeostatic balance and promote survival. However, we now live in a society in which these classic circadian entrainment stimuli have been dramatically altered from the conditions under which the clock machinery was originally set. A bombardment of artificial lighting, heating, and cooling systems that maintain constant ambient temperature; sedentary lifestyle; and the availability of inexpensive, high-calorie foods has threatened even the most powerful and ancient circadian programming mechanisms. Such environmental changes have contributed to the recent staggering elevation in lifestyle-influenced pathologies, including cancer, cardiovascular disease, depression, obesity, and diabetes. This review scrutinizes the role of the body's internal clocks in the hard-wiring of circadian networks that have evolved to achieve energetic balance and adaptability, and it discusses potential therapeutic strategies to reset clock metabolic control to modern time for the benefit of human health. Twit Text FOAVip Circadian metabolism in the light of evolution ????Endocr Rev http://www.kidney.de/pget.php?&tw=1&pmid=25927923 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25927923 #FOAvip English Wikipedia <ref>{{Cite pmid|25927923 }}</ref> Circadian metabolism in the light of evolution #MMPMID25927923 Gerhart-Hines Z ; Lazar MA Endocr Rev 2015[Jun]; 36 (3 ): 289-304 PMID25927923 show ga Circadian rhythm, or daily oscillation, of behaviors and biological processes is a fundamental feature of mammalian physiology that has developed over hundreds of thousands of years under the continuous evolutionary pressure of energy conservation and efficiency. Evolution has fine-tuned the body's clock to anticipate and respond to numerous environmental cues in order to maintain homeostatic balance and promote survival. However, we now live in a society in which these classic circadian entrainment stimuli have been dramatically altered from the conditions under which the clock machinery was originally set. A bombardment of artificial lighting, heating, and cooling systems that maintain constant ambient temperature; sedentary lifestyle; and the availability of inexpensive, high-calorie foods has threatened even the most powerful and ancient circadian programming mechanisms. Such environmental changes have contributed to the recent staggering elevation in lifestyle-influenced pathologies, including cancer, cardiovascular disease, depression, obesity, and diabetes. This review scrutinizes the role of the body's internal clocks in the hard-wiring of circadian networks that have evolved to achieve energetic balance and adaptability, and it discusses potential therapeutic strategies to reset clock metabolic control to modern time for the benefit of human health. |*Biological Evolution [MESH] |*Environment [MESH] |Animals [MESH] |Brain/physiology [MESH] |Circadian Clocks/*physiology [MESH] |Circadian Rhythm/*physiology [MESH]Circadian metabolism in the light of evolution (epmc).pdf DeepDyve Pubget Overpricing