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10.3109/07853890.2014.914808 http://scihub22266oqcxt.onion/10.3109/07853890.2014.914808 C4153443!4153443 !24901356     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24901356 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24901356 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Ann+Med 2014 ; 46 (4 ): 208-20 Nephropedia Template TP {{tp|p=24901356 |t=2014. Circadian gene variants in cancer |pdf=|usr=}}{{24901356 }} gab.com Text Circadian gene variants in cancer JO: Ann Med http://www.kidney.de/pget.php?&tw=1&pmid=24901356 #FOAvip Humans as diurnal beings are active during the day and rest at night. This daily oscillation of behavior and physiology is driven by an endogenous circadian clock not environmental cues. In modern societies, changes in lifestyle have led to a frequent disruption of the endogenous circadian homeostasis leading to increased risk of various diseases including cancer. The clock is operated by the feedback loops of circadian genes and controls daily physiology by coupling cell proliferation and metabolism, DNA damage repair, and apoptosis in peripheral tissues with physical activity, energy homeostasis, immune and neuroendocrine functions at the organismal level. Recent studies have revealed that defects in circadian genes due to targeted gene ablation in animal models or single nucleotide polymorphism, deletion, deregulation and/or epigenetic silencing in humans are closely associated with increased risk of cancer. In addition, disruption of circadian rhythm can disrupt the molecular clock in peripheral tissues in the absence of circadian gene mutations. Circadian disruption has recently been recognized as an independent cancer risk factor. Further study of the mechanism of clock-controlled tumor suppression will have a significant impact on human health by improving the efficiencies of cancer prevention and treatment. Twit Text FOAVip Circadian gene variants in cancer ????Ann Med http://www.kidney.de/pget.php?&tw=1&pmid=24901356 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24901356 #FOAvip English Wikipedia <ref>{{Cite pmid|24901356 }}</ref> Circadian gene variants in cancer #MMPMID24901356 Kettner NM ; Katchy CA ; Fu L Ann Med 2014[Jun]; 46 (4 ): 208-20 PMID24901356 show ga Humans as diurnal beings are active during the day and rest at night. This daily oscillation of behavior and physiology is driven by an endogenous circadian clock not environmental cues. In modern societies, changes in lifestyle have led to a frequent disruption of the endogenous circadian homeostasis leading to increased risk of various diseases including cancer. The clock is operated by the feedback loops of circadian genes and controls daily physiology by coupling cell proliferation and metabolism, DNA damage repair, and apoptosis in peripheral tissues with physical activity, energy homeostasis, immune and neuroendocrine functions at the organismal level. Recent studies have revealed that defects in circadian genes due to targeted gene ablation in animal models or single nucleotide polymorphism, deletion, deregulation and/or epigenetic silencing in humans are closely associated with increased risk of cancer. In addition, disruption of circadian rhythm can disrupt the molecular clock in peripheral tissues in the absence of circadian gene mutations. Circadian disruption has recently been recognized as an independent cancer risk factor. Further study of the mechanism of clock-controlled tumor suppression will have a significant impact on human health by improving the efficiencies of cancer prevention and treatment. |Animals [MESH] |Circadian Clocks/*genetics/physiology [MESH] |Circadian Rhythm/*genetics/physiology [MESH] |Genetic Variation [MESH] |Homeostasis/physiology [MESH] |Humans [MESH] |Mutation [MESH] |Neoplasms/*genetics/pathology [MESH]Circadian gene variants in cancer (epmc).pdf DeepDyve Pubget Overpricing