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10.1021/bi5007354 http://scihub22266oqcxt.onion/10.1021/bi5007354 C4303322!4303322 !25302769     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25302769 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Biochemistry 2015 ; 54 (2 ): 110-23 Nephropedia Template TP {{tp|p=25302769 |t=2015. Circadian clock, cancer, and chemotherapy |pdf=|usr=}}{{25302769 }} gab.com Text Circadian clock, cancer, and chemotherapy JO: Biochemistry http://www.kidney.de/pget.php?&tw=1&pmid=25302769 #FOAvip The circadian clock is a global regulatory system that interfaces with most other regulatory systems and pathways in mammalian organisms. Investigations of the circadian clock-DNA damage response connections have revealed that nucleotide excision repair, DNA damage checkpoints, and apoptosis are appreciably influenced by the clock. Although several epidemiological studies in humans and a limited number of genetic studies in mouse model systems have indicated that clock disruption may predispose mammals to cancer, well-controlled genetic studies in mice have not supported the commonly held view that circadian clock disruption is a cancer risk factor. In fact, in the appropriate genetic background, clock disruption may instead aid in cancer regression by promoting intrinsic and extrinsic apoptosis. Finally, the clock may affect the efficacy of cancer treatment (chronochemotherapy) by modulating the pharmacokinetics and pharmacodynamics of chemotherapeutic drugs as well as the activity of the DNA repair enzymes that repair the DNA damage caused by anticancer drugs. Twit Text FOAVip Circadian clock, cancer, and chemotherapy ????Biochemistry http://www.kidney.de/pget.php?&tw=1&pmid=25302769 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25302769 #FOAvip English Wikipedia <ref>{{Cite pmid|25302769 }}</ref> Circadian clock, cancer, and chemotherapy #MMPMID25302769 Sancar A ; Lindsey-Boltz LA ; Gaddameedhi S ; Selby CP ; Ye R ; Chiou YY ; Kemp MG ; Hu J ; Lee JH ; Ozturk N Biochemistry 2015[Jan]; 54 (2 ): 110-23 PMID25302769 show ga The circadian clock is a global regulatory system that interfaces with most other regulatory systems and pathways in mammalian organisms. Investigations of the circadian clock-DNA damage response connections have revealed that nucleotide excision repair, DNA damage checkpoints, and apoptosis are appreciably influenced by the clock. Although several epidemiological studies in humans and a limited number of genetic studies in mouse model systems have indicated that clock disruption may predispose mammals to cancer, well-controlled genetic studies in mice have not supported the commonly held view that circadian clock disruption is a cancer risk factor. In fact, in the appropriate genetic background, clock disruption may instead aid in cancer regression by promoting intrinsic and extrinsic apoptosis. Finally, the clock may affect the efficacy of cancer treatment (chronochemotherapy) by modulating the pharmacokinetics and pharmacodynamics of chemotherapeutic drugs as well as the activity of the DNA repair enzymes that repair the DNA damage caused by anticancer drugs. |*Circadian Clocks [MESH] |Animals [MESH] |Antineoplastic Agents/*administration & dosage/pharmacokinetics/pharmacology [MESH] |Apoptosis/drug effects [MESH] |DNA Damage/drug effects [MESH] |DNA Repair Enzymes/metabolism [MESH] |DNA Repair/drug effects [MESH] |Drug Chronotherapy [MESH] |Humans [MESH] |Neoplasms/*drug therapy/epidemiology/*genetics/metabolism [MESH]Circadian clock, cancer, and chemotherapy (epmc).pdf DeepDyve Pubget Overpricing