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2017 ; 6
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): ä Nephropedia Template TP
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Circadian Rhythms and Hormonal Homeostasis: Pathophysiological Implications
#MMPMID28165421
Gnocchi D
; Bruscalupi G
Biology (Basel)
2017[Feb]; 6
(1
): ä PMID28165421
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Over recent years, a deeper comprehension of the molecular mechanisms that
control biological clocks and circadian rhythms has been achieved. In fact, many
studies have contributed to unravelling the importance of the molecular clock for
the regulation of our physiology, including hormonal and metabolic homeostasis.
Here we will review the structure, organisation and molecular machinery that make
our circadian clock work, and its relevance for the proper functioning of
physiological processes. We will also describe the interconnections between
circadian rhythms and endocrine homeostasis, as well as the underlying
consequences that circadian dysregulations might have in the development of
several pathologic affections. Finally, we will discuss how a better knowledge of
such relationships might prove helpful in designing new therapeutic approaches
for endocrine and metabolic diseases.