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10.1016/j.cmet.2015.06.005 http://scihub22266oqcxt.onion/10.1016/j.cmet.2015.06.005 C4558341!4558341 !26166747     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26166747 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26166747 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Metab 2015 ; 22 (3 ): 448-59 Nephropedia Template TP {{tp|p=26166747 |t=2015. Circadian Dysfunction Induces Leptin Resistance in Mice |pdf=|usr=}}{{26166747 }} gab.com Text Circadian Dysfunction Induces Leptin Resistance in Mice JO: Cell Metab http://www.kidney.de/pget.php?&tw=1&pmid=26166747 #FOAvip Circadian disruption is associated with obesity, implicating the central clock in body weight control. Our comprehensive screen of wild-type and three circadian mutant mouse models, with or without chronic jet lag, shows that distinct genetic and physiologic interventions differentially disrupt overall energy homeostasis and Leptin signaling. We found that BMAL1/CLOCK generates circadian rhythm of C/EBP?-mediated leptin transcription in adipose. Per and Cry mutant mice show similar disruption of peripheral clock and deregulation of leptin in fat, but opposite body weight and composition phenotypes that correlate with their distinct patterns of POMC neuron deregulation in the arcuate nucleus. Chronic jet lag is sufficient to disrupt the endogenous adipose clock and also induce central Leptin resistance in wild-type mice. Thus, coupling of the central and peripheral clocks controls Leptin endocrine feedback homeostasis. We propose that Leptin resistance, a hallmark of obesity in humans, plays a key role in circadian dysfunction-induced obesity and metabolic syndromes. Twit Text FOAVip Circadian Dysfunction Induces Leptin Resistance in Mice ????Cell Metab http://www.kidney.de/pget.php?&tw=1&pmid=26166747 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26166747 #FOAvip English Wikipedia <ref>{{Cite pmid|26166747 }}</ref> Circadian Dysfunction Induces Leptin Resistance in Mice #MMPMID26166747 Kettner NM ; Mayo SA ; Hua J ; Lee C ; Moore DD ; Fu L Cell Metab 2015[Sep]; 22 (3 ): 448-59 PMID26166747 show ga Circadian disruption is associated with obesity, implicating the central clock in body weight control. Our comprehensive screen of wild-type and three circadian mutant mouse models, with or without chronic jet lag, shows that distinct genetic and physiologic interventions differentially disrupt overall energy homeostasis and Leptin signaling. We found that BMAL1/CLOCK generates circadian rhythm of C/EBP?-mediated leptin transcription in adipose. Per and Cry mutant mice show similar disruption of peripheral clock and deregulation of leptin in fat, but opposite body weight and composition phenotypes that correlate with their distinct patterns of POMC neuron deregulation in the arcuate nucleus. Chronic jet lag is sufficient to disrupt the endogenous adipose clock and also induce central Leptin resistance in wild-type mice. Thus, coupling of the central and peripheral clocks controls Leptin endocrine feedback homeostasis. We propose that Leptin resistance, a hallmark of obesity in humans, plays a key role in circadian dysfunction-induced obesity and metabolic syndromes. |*Circadian Clocks [MESH] |Adipose Tissue/*metabolism [MESH] |Animals [MESH] |Base Sequence [MESH] |Body Weight [MESH] |CLOCK Proteins/metabolism [MESH] |Circadian Rhythm [MESH] |Energy Metabolism [MESH] |Leptin/blood/genetics/*metabolism [MESH] |Melanocortins/metabolism [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Obesity/blood/genetics/*metabolism [MESH] |Signal Transduction [MESH]Circadian Dysfunction Induces Leptin Resistance in Mice (epmc).pdf DeepDyve Pubget Overpricing