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2015 ; 2015
(ä): 187809
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Circadian Control of Global Transcription
#MMPMID26682214
Li S
; Zhang L
Biomed Res Int
2015[]; 2015
(ä): 187809
PMID26682214
show ga
Circadian rhythms exist in most if not all organisms on the Earth and manifest in
various aspects of physiology and behavior. These rhythmic processes are believed
to be driven by endogenous molecular clocks that regulate rhythmic expression of
clock-controlled genes (CCGs). CCGs consist of a significant portion of the
genome and are involved in diverse biological pathways. The transcription of CCGs
is tuned by rhythmic actions of transcription factors and circadian alterations
in chromatin. Here, we review the circadian control of CCG transcription in five
model organisms that are widely used, including cyanobacterium, fungus, plant,
fruit fly, and mouse. Comparing the similarity and differences in the five
organisms could help us better understand the function of the circadian clock, as
well as its output mechanisms adapted to meet the demands of diverse
environmental conditions.