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2017 ; 14
(8
): 1028-1034
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CircRNAs in the brain
#MMPMID27892769
Hanan M
; Soreq H
; Kadener S
RNA Biol
2017[Aug]; 14
(8
): 1028-1034
PMID27892769
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Circular RNAs (circRNAs) are highly abundant and evolutionarily conserved
non-coding RNAs produced by circularization of specific exons. Since their
re-discovery as potential regulators of gene expression, thousands of circRNAs
were detected in different tissues and cell types across most organisms.
Accumulating data suggest key roles for them in the central nervous system.
Neuronal-expressed RNAs are diverted to yield highly enriched CircRNAs in human,
mouse, pig and flies, with many of them enriched in neuronal tissues. CircRNA
levels are dynamically modulated in neurons, both during differentiation and
following bursts of electrical activity, and accumulate with age, and many of
them are enriched in synapses. Together, available data suggest that circRNAs
have important roles in synaptic plasticity and neuronal function. This review
covers current advances in the field and lays out hypotheses regarding functions
of circRNAs in the brain as well as their putative involvement in initiation and
progression of neurodegenerative processes.
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