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2010 ; 1
(8
): 726-36
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Cilia in cell signaling and human disorders
#MMPMID21203914
Duldulao NA
; Li J
; Sun Z
Protein Cell
2010[Aug]; 1
(8
): 726-36
PMID21203914
show ga
One of the most widespread cellular organelles in nature is cilium, which is
found in many unicellular and multicellular organisms. Formerly thought to be a
mostly vestigial organelle, the cilium has been discovered in the past several
decades to play critical motile and sensory roles involved in normal
organogenesis during development. The role of cilia has also been implicated in
an ever increasing array of seemingly unrelated human diseases, including
blindness, kidney cysts, neural tube defects and obesity. In this article we
review some of the recent developments in research on cilia, and how defects in
ciliogenesis and function can give rise to developmental disorders and disease.