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10.1007/s13238-010-0098-7

http://scihub22266oqcxt.onion/10.1007/s13238-010-0098-7
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suck abstract from ncbi


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pmid21203914
      Protein+Cell 2010 ; 1 (8 ): 726-36
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  • Cilia in cell signaling and human disorders #MMPMID21203914
  • Duldulao NA ; Li J ; Sun Z
  • Protein Cell 2010[Aug]; 1 (8 ): 726-36 PMID21203914 show ga
  • One of the most widespread cellular organelles in nature is cilium, which is found in many unicellular and multicellular organisms. Formerly thought to be a mostly vestigial organelle, the cilium has been discovered in the past several decades to play critical motile and sensory roles involved in normal organogenesis during development. The role of cilia has also been implicated in an ever increasing array of seemingly unrelated human diseases, including blindness, kidney cysts, neural tube defects and obesity. In this article we review some of the recent developments in research on cilia, and how defects in ciliogenesis and function can give rise to developmental disorders and disease.
  • |*Signal Transduction [MESH]
  • |Abnormalities, Multiple/pathology [MESH]
  • |Animals [MESH]
  • |Cerebellar Diseases/genetics/pathology [MESH]
  • |Cilia/*physiology/ultrastructure [MESH]
  • |Flagella/physiology [MESH]
  • |Hedgehog Proteins/metabolism [MESH]
  • |Humans [MESH]
  • |Models, Animal [MESH]
  • |Polycystic Kidney Diseases/pathology [MESH]
  • |Protein Transport [MESH]


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