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2016 ; 101
(5
): 541-58
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gab.com Text
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English Wikipedia
Chronic myeloid leukemia: reminiscences and dreams
#MMPMID27132280
Mughal TI
; Radich JP
; Deininger MW
; Apperley JF
; Hughes TP
; Harrison CJ
; Gambacorti-Passerini C
; Saglio G
; Cortes J
; Daley GQ
Haematologica
2016[May]; 101
(5
): 541-58
PMID27132280
show ga
With the deaths of Janet Rowley and John Goldman in December 2013, the world lost
two pioneers in the field of chronic myeloid leukemia. In 1973, Janet Rowley,
unraveled the cytogenetic anatomy of the Philadelphia chromosome, which
subsequently led to the identification of the BCR-ABL1 fusion gene and its
principal pathogenetic role in the development of chronic myeloid leukemia. This
work was also of major importance to support the idea that cytogenetic changes
were drivers of leukemogenesis. John Goldman originally made seminal
contributions to the use of autologous and allogeneic stem cell transplantation
from the late 1970s onwards. Then, in collaboration with Brian Druker, he led
efforts to develop ABL1 tyrosine kinase inhibitors for the treatment of patients
with chronic myeloid leukemia in the late 1990s. He also led the global efforts
to develop and harmonize methodology for molecular monitoring, and was an
indefatigable organizer of international conferences. These conferences brought
together clinicians and scientists, and accelerated the adoption of new
therapies. The abundance of praise, tributes and testimonies expressed by many
serve to illustrate the indelible impressions these two passionate and affable
scholars made on so many people's lives. This tribute provides an outline of the
remarkable story of chronic myeloid leukemia, and in writing it, it is clear that
the historical triumph of biomedical science over this leukemia cannot be
considered without appreciating the work of both Janet Rowley and John Goldman.
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