Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29642749
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Mol+Pain
2018 ; 14
(ä): 1744806918767697
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Chronic migraine: A process of dysmodulation and sensitization
#MMPMID29642749
Su M
; Yu S
Mol Pain
2018[Jan]; 14
(ä): 1744806918767697
PMID29642749
show ga
Chronic migraine is a common chronic daily headache featured by frequent headache
attacks with at least 15 headache days per month, which brings great disease
burden to both the sufferers and the society. Transformed from episodic migraine,
the pathophysiology of chronic migraine is not fully understood, even though
several risk factors have been associated with migraine progression. Recent
studies have identified both structural and functional alterations in some brain
regions of chronic migraine patients indicating that maladaptation of the
top-down pain modulation and subsequent sensitization of trigeminal system may be
important in the pathogenesis of chronic migraine. Moreover, biochemical analysis
has confirmed several molecules related to chronic migraine, which may serve as
biomarkers and potential therapeutic targets. Chronic migraine is undertreated
because of its poor treatment response and limited therapy options. In this
article, we reviewed the latest data to outline the clinical feature,
pathophysiological mechanism, and management of chronic migraine, in the
expectation to provide direction for future research and finally to take good
care of chronic migraine patients.
free
free
free
