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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Allergy+Clin+Immunol+Pract
2016 ; 4
(4
): 575-82
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Chronic Rhinosinusitis without Nasal Polyps
#MMPMID27393771
Cho SH
; Kim DW
; Gevaert P
J Allergy Clin Immunol Pract
2016[Jul]; 4
(4
): 575-82
PMID27393771
show ga
Chronic rhinosinusitis without nasal polyps (CRSsNP) is more prevalent than
chronic rhinosinusitis with nasal polyps (CRSwNP). Certain diseases predispose to
whereas others are associated with CRSsNP. Predisposing diseases include allergic
and nonallergic upper and lower airway diseases, epithelial cell disorders,
immunodeficiencies, autoimmune diseases, and some infectious diseases. In
addition, environmental and host factors, examples of which include smoking, a
higher incidence of abnormal biofilms, and innate immune defects, play a role in
the pathogenesis of this disease. CRSsNP is characterized by histologic
abnormalities, including basement membrane thickening (fibrosis) and goblet cell
hyperplasia. Neutrophils and several chemokines, TGF-? and C-X-C motif chemokine
ligand (CXCL)-8, play a role in CRSsNP remodeling. However, there are conflicting
data about CRSsNP endotypes, for example, whether it is characterized by
neutrophilia or eosinophilia or both. In spite of advancements and the
understanding of the pathogenesis of this disease, additional study is necessary
to better comprehend its underlying mechanisms, endotypes, and evidence-based
treatment strategies.
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