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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Allergy+Clin+Immunol+Pract
2016 ; 4
(4
): 565-72
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Chronic Rhinosinusitis with Nasal Polyps
#MMPMID27393770
Stevens WW
; Schleimer RP
; Kern RC
J Allergy Clin Immunol Pract
2016[Jul]; 4
(4
): 565-72
PMID27393770
show ga
Chronic rhinosinusitis with nasal polyps (CRSwNP) is an important clinical entity
diagnosed by the presence of both subjective and objective evidence of chronic
sinonasal inflammation. Symptoms include anterior or posterior rhinorrhea, nasal
congestion, hyposmia, and/or facial pressure or pain that last for a duration of
more than 12 weeks. Nasal polyps are inflammatory lesions that project into the
nasal airway, are typically bilateral, and originate from the ethmoid sinus.
Males are more likely to be affected than females, but no specific genetic or
environmental factors have been strongly linked to the development of this
disorder to date. CRSwNP is frequently associated with asthma and allergic
rhinitis, but the cellular and molecular mechanisms that contribute to the
clinical symptoms are not fully understood. Defects in the sinonasal epithelial
cell barrier, increased exposure to pathogenic and colonized bacteria, and
dysregulation of the host immune system are all thought to play prominent roles
in disease pathogenesis. Additional studies are needed to further explore the
clinical and pathophysiological features of CRSwNP so that biomarkers can be
identified and novel advances can be made to improve the treatment and management
of this disease.
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