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Chronic Pancreatitis and Pancreatic Cancer
#MMPMID26674754
Kong X
; Sun T
; Kong F
; Du Y
; Li Z
Gastrointest Tumors
2014[Aug]; 1
(3
): 123-34
PMID26674754
show ga
BACKGROUND: Pancreatic cancer (PC) is one of the most lethal diseases with an
incidence rate almost equal to the rate of mortality. Chronic pancreatitis (CP)
is a common chronic inflammatory disease of unknown etiology that affects the
pancreas. Epidemiological studies have identified CP to be a major risk factor
for PC. SUMMARY: A greater understanding of the molecular mechanisms linking CP
and PC has identified several common pathways that provide targets for future
interventions. This article reviews those components in the CP-PC connection,
including the role of macrophages, the maintenance of genome stability,
cytokines, and other nodal factors such as nuclear factor kappa B, COX-2 and
reactive oxygen species. KEY MESSAGE: The molecular mechanisms that underlie CP
and PC provide novel targets for future therapies for PC. PRACTICAL IMPLICATIONS:
The stromal-desmoplastic reaction plays an important role in initiating and
sustaining chronic inflammation and tumor progression. Recently, two targeted
anti-tumor agents, erlotinib and nab-paclitaxel, have shown promising therapeutic
efficacy. Notably, both these agents target components (EGFR and SPARC) within
the inflammatory stroma surrounding malignant cells, underscoring the importance
of inflammation in pancreatic carcinogenesis. Identifying the common pathways
linking CP and PC may help uncover additional novel targets for future therapies.
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