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2017 ; 18
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Chronic Kidney Disease and Exposure to Nephrotoxic Metals
#MMPMID28498320
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; Bridges CC
Int J Mol Sci
2017[May]; 18
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): ä PMID28498320
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Chronic kidney disease (CKD) is a common progressive disease that is typically
characterized by the permanent loss of functional nephrons. As injured nephrons
become sclerotic and die, the remaining healthy nephrons undergo numerous
structural, molecular, and functional changes in an attempt to compensate for the
loss of diseased nephrons. These compensatory changes enable the kidney to
maintain fluid and solute homeostasis until approximately 75% of nephrons are
lost. As CKD continues to progress, glomerular filtration rate decreases, and
remaining nephrons are unable to effectively eliminate metabolic wastes and
environmental toxicants from the body. This inability may enhance mortality
and/or morbidity of an individual. Environmental toxicants of particular concern
are arsenic, cadmium, lead, and mercury. Since these metals are present
throughout the environment and exposure to one or more of these metals is
unavoidable, it is important that the way in which these metals are handled by
target organs in normal and disease states is understood completely.
|Animals
[MESH]
|Environmental Exposure/adverse effects
[MESH]
|Heavy Metal Poisoning/complications/*metabolism/physiopathology
[MESH]
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