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2016 ; 7
(ä): 210
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Chronic Inflammation and ?? T Cells
#MMPMID27303404
Fay NS
; Larson EC
; Jameson JM
Front Immunol
2016[]; 7
(ä): 210
PMID27303404
show ga
The epithelial tissues of the skin, lungs, reproductive tract, and intestines are
the largest physical barriers the body has to protect against infection.
Epithelial tissues are woven with a matrix of immune cells programed to mobilize
the host innate and adaptive immune responses. Included among these immune cells
are gamma delta T lymphocytes (?? T cells) that are unique in their T cell
receptor usage, location, and functions in the body. Stress reception by ?? T
cells as a result of traumatic epithelial injury, malignancy, and/or infection
induces ?? T cell activation. Once activated, ?? T cells function to repair
tissue, induce inflammation, recruit leukocytes, and lyse cells. Many of these
functions are mediated via the production of cytokines and growth factors upon ??
T cell activation. Pathogenesis of many chronic inflammatory diseases involves ??
T cells; some of which are exacerbated by their presence, while others are
improved. ?? T cells require a delicate balance between their need for acute
inflammatory mediators to function normally and the detrimental impact imparted
by chronic inflammation. This review will focus on the recent progress made in
understanding how epithelial ?? T cells influence the pathogenesis of chronic
inflammatory diseases and how a balance between acute and chronic inflammation
impacts ?? T cell function. Future studies will be important to understand how
this balance is achieved.