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2016 ; 7
(3
): 63-8
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Chromatin structure and pre-mRNA processing work together
#MMPMID27028548
Jimeno-González S
; Reyes JC
Transcription
2016[May]; 7
(3
): 63-8
PMID27028548
show ga
Chromatin is the natural context for transcription elongation. However, the
elongating RNA polymerase II (RNAPII) is forced to pause by the positioned
nucleosomes present in gene bodies. Here, we briefly discuss the current results
suggesting that those pauses could serve as a mechanism to coordinate
transcription elongation with pre-mRNA processing. Further, histone
post-translational modifications have been found to regulate the recruitment of
factors involved in pre-mRNA processing. This view highlights the important
regulatory role of the chromatin context in the whole process of the mature mRNA
synthesis.