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10.1080/21541264.2016.1168507

http://scihub22266oqcxt.onion/10.1080/21541264.2016.1168507
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C4984687!4984687 !27028548
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suck abstract from ncbi


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pmid27028548
      Transcription 2016 ; 7 (3 ): 63-8
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  • Chromatin structure and pre-mRNA processing work together #MMPMID27028548
  • Jimeno-González S ; Reyes JC
  • Transcription 2016[May]; 7 (3 ): 63-8 PMID27028548 show ga
  • Chromatin is the natural context for transcription elongation. However, the elongating RNA polymerase II (RNAPII) is forced to pause by the positioned nucleosomes present in gene bodies. Here, we briefly discuss the current results suggesting that those pauses could serve as a mechanism to coordinate transcription elongation with pre-mRNA processing. Further, histone post-translational modifications have been found to regulate the recruitment of factors involved in pre-mRNA processing. This view highlights the important regulatory role of the chromatin context in the whole process of the mature mRNA synthesis.
  • |Chromatin/*chemistry/genetics [MESH]
  • |Histone Code [MESH]
  • |Histones/metabolism [MESH]
  • |Humans [MESH]
  • |RNA Polymerase II/*metabolism [MESH]
  • |RNA Processing, Post-Transcriptional [MESH]
  • |RNA, Messenger/chemistry/*metabolism [MESH]


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