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10.1101/gad.255182.114 http://scihub22266oqcxt.onion/10.1101/gad.255182.114 C4318141!4318141 !25644600     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25644600 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25644600 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Genes+Dev 2015 ; 29 (3 ): 238-49 Nephropedia Template TP {{tp|p=25644600 |t=2015. Chromatin signatures of cancer |pdf=|usr=}}{{25644600 }} gab.com Text Chromatin signatures of cancer JO: Genes Dev http://www.kidney.de/pget.php?&tw=1&pmid=25644600 #FOAvip Changes in the pattern of gene expression play an important role in allowing cancer cells to acquire their hallmark characteristics, while genomic instability enables cells to acquire genetic alterations that promote oncogenesis. Chromatin plays central roles in both transcriptional regulation and the maintenance of genomic stability. Studies by cancer genome consortiums have identified frequent mutations in genes encoding chromatin regulatory factors and histone proteins in human cancer, implicating them as major mediators in the pathogenesis of both hematological malignancies and solid tumors. Here, we review recent advances in our understanding of the role of chromatin in cancer, focusing on transcriptional regulatory complexes, enhancer-associated factors, histone point mutations, and alterations in heterochromatin-interacting factors. Twit Text FOAVip Chromatin signatures of cancer ????Genes Dev http://www.kidney.de/pget.php?&tw=1&pmid=25644600 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25644600 #FOAvip English Wikipedia <ref>{{Cite pmid|25644600 }}</ref> Chromatin signatures of cancer #MMPMID25644600 Morgan MA ; Shilatifard A Genes Dev 2015[Feb]; 29 (3 ): 238-49 PMID25644600 show ga Changes in the pattern of gene expression play an important role in allowing cancer cells to acquire their hallmark characteristics, while genomic instability enables cells to acquire genetic alterations that promote oncogenesis. Chromatin plays central roles in both transcriptional regulation and the maintenance of genomic stability. Studies by cancer genome consortiums have identified frequent mutations in genes encoding chromatin regulatory factors and histone proteins in human cancer, implicating them as major mediators in the pathogenesis of both hematological malignancies and solid tumors. Here, we review recent advances in our understanding of the role of chromatin in cancer, focusing on transcriptional regulatory complexes, enhancer-associated factors, histone point mutations, and alterations in heterochromatin-interacting factors. |Animals [MESH] |Chromatin/*genetics/*metabolism [MESH] |Histones/genetics/metabolism [MESH] |Humans [MESH] |Mutation [MESH] |Neoplasms/*genetics/physiopathology [MESH]Chromatin signatures of cancer (epmc).pdf DeepDyve Pubget Overpricing